Our lab is interested in chromosome dynamics in bacteria. Using Bacillus subtilis as a model organism, we combine genetic, molecular, cytological, and biochemical approaches to study how the chromosome is organized and segregated during the cell cycle. Our research primarily focuses on a set of highly conserved factors in chromosome biology, including the parABS partitioning system and the SMC condensin complex. Taking the many strengths of studying bacteria, our goal is to uncover general principles of chromosome organization and segregation in living organisms.
Chromosome organization and segregation during the replication cycle
Identifying and characterizing novel factors involved in chromosome biology
Molecular mechanism of chromosome packaging
Chromosome folding during growth and development